Complement resolves immunological problems, yet over-activation may lead to these diseases:

• Renal: Diabetic Nephropathy, Lupus Nephritis 

• Neurological & autoimmune: Myasthenia Gravis (MG), Multiple Sclerosis (MS), Neuromyelitis Optica (NMO)

• Retinal: Age-related macular degeneration (AMD)

• Cognitive: Alzheimer’s Disease (AD), Prodromal Schizophrenia (SZ)